Epileptic seizures and survival in early disease of grade 2 gliomas |
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Authors: | T. Danfors D. Ribom S. G. Berntsson A. Smits |
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Affiliation: | Department of Neuroscience, Neurology, University Hospital, Uppsala, Sweden;;and Department of Neurology, Länssjukhuset, Halmstad, Sweden |
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Abstract: | Background and purpose: The aims of this study were (i) to determine the correlation between seizure activity and the metabolic rate of the tumour measured by 11C-methionine PET (MET PET) in patients with grade 2 gliomas, and (ii) to assess the prognostic impact of early seizure manifestations on patient survival. Methods: In this retrospective review, early seizure manifestations were studied in 101 patients with supratentorial grade 2 gliomas subjected to MET PET as part of the pre-treatment tumour investigation. Seizure manifestations as a variable was then used in multivariate survival analyses, together with established prognostic factors for this patient group. Results: Of all 101 cases, 88 patients had seizures at tumour presentation. Forty-seven were seizure free at the early stage of the disease, whereas 54 had recurrent seizures. Patients with seizures at tumour presentation had a more favourable outcome before and after ( P = 0.006) adjustment for conventional prognostic factors. However, for those who continued to have seizures early in the disease, the outcome was worse ( P = 0.003). We found no significant correlation between MET PET and the seizure manifestations of the patients. Conclusion: The presence and termination of early seizure manifestations may be favourable prognostic factors in patients with low-grade gliomas. |
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Keywords: | 11C methionine positron emission tomography epileptic seizures low-grade glioma survival |
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