| 三氧化二砷对人骨髓增生异常综合征MUTZ-1细胞的作用 |
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| 引用本文： | 王巍. 三氧化二砷对人骨髓增生异常综合征MUTZ-1细胞的作用[J]. 吉林医学, 2005, 26(12): 1262-1264 |
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| 作者姓名： | 王巍 |
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| 作者单位： | 长春市中心医院,吉林长春130061 |
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| 摘 要： | 目的:研究不同浓度三氧化二砷(As2O3)对人骨髓增生异常综合征难治性贫血伴原始细胞过多型(MDS-RAEB)细胞株MUTZ-1细胞增殖的影响,并探讨其可能的作用机制。方法:采用MTT法分析细胞生长曲线,用细胞形态学观察细胞凋亡。结果:低浓度As2O3(0.05～0.25μmol/L)对MUTZ-1细胞无明显生长抑制作用,高浓度As2O3(1.0～20.0μmol/L)对MUTZ-1细胞有明显生长抑制作用,且呈浓度、时间效应-依赖关系(P<0.01)。结论:低浓度As2O3(0.05～0.25μmol/L)对MUTZ-1细胞无明显生长抑制作用。高浓度As2O3(1.0～20.0μmol/L)对MUTZ-1细胞有明显生长抑制作用,且呈浓度、时间效应依赖关系。
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| 关 键 词： | 骨髓增生异常综合征 三氧化二砷 细胞凋亡 |
| 文章编号： | 1004-0412（2005）12-1262-03 |
| 收稿时间： | 2005-07-04 |
| 修稿时间： | 2005-07-04 |
The effect of arsenic trioxide on MDS line MUTZ-1 cellsline |
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| WANG Wei. The effect of arsenic trioxide on MDS line MUTZ-1 cellsline[J]. Jilin Medical Journal, 2005, 26(12): 1262-1264 |
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| Authors: | WANG Wei |
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| Affiliation: | Blood Department ,Central Hospital of Changchun City, Changchun 130061,China |
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| Abstract: | Objective To investigate the inhibition effect of As2O3 on the growth of human MDS-RAEB cell line MUTZ-1 cells and to explore the possible cellular and molecular mechanisms.Method The experiment use the method of MTT to investigate the inhibition effect of arsenic trioxide(As2O3)on the growth of human MDS-RAEB cellline MUTZ-1 cells and to explore the possible cellular and molecular mechanism.Results Low concentration of As2O3(0.05～0.25μmol/L)had no marked growth inhibition effect on MUTZ-1 cells,high concentration of As2O3(1.0～20.0μmol/L)had marked growth inhibition effect on MUTZ-1 cells.After 48h treatment with2.0μmol/L As2O3.Conclusion Low concentration of As2O3(0.05～0.25μmol/L)had no marked growth inhibition effect on MUTZ-1 cells,high concentration of As2O3(1.0～20.0μmol/L)had marked growth inhibition effect on MUTZ-1 cells. |
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| Keywords: | Myelodysplastic Syndromes arsenicals Apoptosis |
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