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| 高效液相色谱法测定复方妥英麻黄茶碱胶囊中生物碱的含量 | |
| 引用本文： | 侯小虎,梁泰刚,李青山,王建平.高效液相色谱法测定复方妥英麻黄茶碱胶囊中生物碱的含量[J].山西职工医学院学报,2014(5):1-6. |
| 作者姓名： | 侯小虎 梁泰刚 李青山 王建平 |
| 作者单位： | 1. 山西医科大学第三医院,山西 太原,030053 2. 山西医科大学,山西 太原,030001 3. 山西省第二人民医院,山西 太原,030012 |
| 摘 要： | 目的：建立高效液相色谱法测定复方妥英麻黄茶碱胶囊中生物碱的含量。方法：采用Diamonsil C18（150 mm×4.6 mm,5μm）色谱柱,以甲醇-0.05 mol/L磷酸二氢钾-三乙胺（30∶70∶0.2）为流动相,检测波长为215 nm,流速为1.0 m L/min,柱温为室温。结果：每粒含可可碱、盐酸麻黄碱、茶碱、咖啡因均为标示量的90.0%-110.0%。结论：本方法简便,结果准确可靠,是本制剂质量控制的有效方法。 |
| 关 键 词： | 复方妥英麻黄茶碱胶囊 高效液相色谱法 含量 |
HPLC Determination of Alkaloid in Compound Tuoyin Mahuang Chajian Capsules |
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| HOU Xiaohu,LIANG Taigang,LI Qingshan,WANG Jianping.HPLC Determination of Alkaloid in Compound Tuoyin Mahuang Chajian Capsules[J].Journal of Shanxi Medical College For Continuing Education,2014(5):1-6. | |
| Authors: | HOU Xiaohu LIANG Taigang LI Qingshan WANG Jianping |
| Institution: | HOU Xiaohu, LIANG Taigang, LI Qingshan, WANG Jianping ( 1. The Third Hospital of Shanxi Medical University, Taiyuan 030053, Shanxi, China ; 2. Shanxi Medical University , Taiyuan 030001, Shanxi , China; 3. The Second People＇s Hospital of Shanxi Province, Taiyuan 030012 ,Shanxi, China) |
| Abstract: | Objective：To establish a method for the determination of alkaloids in compound tuoyin mahuang chajian capsules by HPLC（ high performance liquid chromatography）. Methods：A column of Diamonsil C18（150 mm × 4. 6 mm,5 μm）was used. The mobile phase consisted of methanol -0. 05 mol/L Potassium dihydrogen phosphate-Tri-ethylamine（30：70：0. 2）and the flow rate was 1. 0 mL·min^-1 . The UV detection wavelength was 215 nm and column temperature was room-temperature. Result：Theobromine,ephedrine hydrochloride,theophylline,caffeine containing in each capsule were the amount of 90. 0% -110. 0% labeled. Conclusion：The method is simple,accurate,useful in quality control for the capsules. |
| Keywords: | compound tuoyin mahuang chajian capsules HPLC determination |
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