| 外周阿片类药镇痛的研究进展 |
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| 引用本文： | 吴韬,金耀君,尤新民,金熊元.外周阿片类药镇痛的研究进展[J].国际麻醉学与复苏杂志,2007,28(3):267-269. |
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| 作者姓名： | 吴韬 金耀君 尤新民 金熊元 |
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| 作者单位： | 200092,上海交通大学医学院附属新华医院麻醉科 |
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| 摘 要： | 外周感觉神经的阿片受体受炎症的调控。位于炎性组织范围内的免疫细胞表达阿片肽,与感觉神经上的阿片受体结合,通过抑制这些神经的兴奋性和（或）炎症前神经肽的释放而产生镇痛作用。现简要介绍外周阿片类药镇痛,并探讨其与临床药理学的联系。在临床药理学的研究中,我们要充分应用外周阿片类药镇痛,克服它的局限性,以此推动外周阿片类药应用在临床镇痛的发展。
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| 关 键 词： | 外周阿片受体 镇痛 炎症 |
Advance in peripheral opioid analgesia |
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| WU Tao, JIN Yao-jun, YOU Xin-min,et al..Advance in peripheral opioid analgesia[J].international journal of anesthesiology and resuscitation,2007,28(3):267-269. |
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| Authors: | WU Tao JIN Yao-jun YOU Xin-min |
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| Institution: | Department of Anesthesiology, Xinhua Hospital, Medical College of Jiaotong University, Shanghai 200092, China |
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| Abstract: | Peripheral opioid receptors of peripheral sensory nerve are regulated by inflammation. Opioid peptide produced by immunocytes in inflammatory tissue combines to peripheral opioid receptor. This combination exerts analgesia by inhibiting the excitability of peripheral sensory nerve and/or the release of preinflammatory neurokinin. This article briefly introduces the conception of peripheral opioid analgesia (POA) and its action mechanism. The relationship between POA and their clinical pharmacology is also discussed. |
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| Keywords: | peripheral opioid receptor analgesia inflammation |
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