PCNA、PTTG、c—myc、p53在垂体腺瘤中的表达及其与肿瘤复发的关系

目的探讨增殖细胞核抗原(PCNA)、垂体腺瘤转化基因(PTTG)、c-myc、p53与垂体腺瘤侵袭、增殖能力及复发的关系。方法采用免疫组化方法检测PCNA、PTTG、c-myc、p53在侵袭性、非侵袭性及复发性垂体腺瘤中的表达。结果PTTG和PCNA表达水平在侵袭性和复发性垂体腺瘤中显著高于非侵袭性垂体腺瘤(P<0.05),而在复发性垂体腺瘤组与侵袭性垂体腺瘤组之间无明显差异(P>0.05)。c-myc的表达在侵袭性、非侵袭性和复发性垂体腺瘤各组之间均无明显差异(P>0.05)。p53在复发性垂体腺瘤中的表达明显高于侵袭性和非侵袭性垂体腺瘤(P<0.05)。结论PTTG和PCNA与垂体腺瘤侵袭性和增殖能力密切相关,而c-myc和p53还不能作为评价垂体腺瘤侵袭性的指标。

Expressions of PCNA, PTTG, c-myc, p53 in Pituitary Adenomas and Their Relationship with the Adenomas Recurrency

Objective To investigate the relationship of proliferating cell nuclear antigen(PCNA),pituitary tumor transforming gene(PTTG),c-myc and p53 with invasiveness,proliferation and recurrency of pituitary adenomas.Methods Immunohistochemical techniques were used to detect the expressions of PCNA,PTTG,c-myc and p53 in 60 cases of pituitary adenomas including 30 cases of invasive tumors,25 cases of non-invasive tumors and 5 cases of recurrent tumors.Results The expressions of PCNA and PTTG in the invasive tumors and recurrent tumors groups were significantly higher than those in the non-invasive tumors group(P<0.05).There was insignificant difference in the expressions of PCNA and PTTG between both the of invasive and recurrent tumors groups(P>0.05).There was insignificant difference in the expression of c-myc among the invasive,non-invasive and recurrent tumors groups(P>0.05).The expressions of p53 was significantly higher in the recurrent tumors groups than that in the invasive and non-invasive tumors groups.Conclusion The expressions of PTTG and PCNA correlates closely with the invasiveness and proliferation in human pituitary adenomas,whereas c-myc and p53 are not ideal indexs of tumor invasiveness.