脯氨酰寡肽酶抑制剂的研究进展

目的综述脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床研究等方面的进展。方法根据国外相关文献 ,对脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床试验情况进行整理和归纳。结果脯氨酰寡肽酶抑制剂可通过设计合成或从天然药物的筛选中得到 ,数种口服抑制剂正在进行治疗Alzhermer’s病的临床试验。结论脯氨酰寡肽酶抑制剂有望成为新一代治疗Alzhermer’s病的重要药物

Advances of the study on prolyl oligopeptidase inhibitors

Objective To review advances of the study on prolyl oligopeptidase inhibitors,including evaluation of their structure-activity relationships,natural active constituents,and their clinical studies.Method By the international literature,the structure-activity relationships of prolyl oligopeptidase inhibitors,natural active constituents,and clinical studies were summed up.Results Prolyl oligopeptidase inhibitors could be developed from design and synthesis,or from screening of crude drugs,several orally active prolyl endopeptidase inhibitors are under clinical studies.Conclusion Prolyl endopeptidase inhibitors are expected to be new therapeutic drugs for the Alzhermer's disease.