电离辐射诱导的细胞G2期阻滞

哺乳动物受X射线照射后,可以使细胞周期延迟或阻滞,包括G1期阻滞、S期延迟和G2期阻滞。G1期阻滞仅在野生型p53基因存在时出现,在清除DNA损伤的细胞中具有重要作用;而G2期阻滞更有利于损伤后DNA的修复和细胞存活,并且与p53基因存在状态无关。因此,对电离辐射诱导细胞G2期阻滞机制的探讨成为近年来国内外放射生物学领域的研究热点。

G2 phase arrest of cell cycle induced by ionizing radiation

The exposure of mammalian cells to X rays results in the prolongation of the cell cycle,including the delay or the arrest in G 1 ,S and G 2 phase.The major function of G 1 arrest may be to eliminate the cells containing DNA damage and only occurs in the cells with wild type p53function whereas G 2 arrest following ionizing radiation has been shown to be important in protecting the cells from death and occurs in all cells regardless of p53status.So the study on G 2 phase arrest of the cell cycle induced by ionizing radiation has currently become a focus at radiobiological fields.