Subcellular distribution of the immunoreactive peptide histidine isoleucine in the rat brain and release from synaptosomes in vitro |
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| Authors: | T Inoue Y Kato Y Tatsuoka A Shimatsu H Imura |
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| Affiliation: | Second Medical Clinic, Department of Medicine, Kyoto University, Faculty of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606 Japan |
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| Abstract: | Subcellular fractionation studies of rat brain homogenate revealed that peptide histidine isoleucine-like immunoreactivity (PHI-LI) was enriched in synaptosomal preparations. PHI-LI was released by high potassium concentrations from synaptosomal pellets incubated in vitro. These results suggest a possible physiological role of PHI in the central nervous system as a neurotransmitter or modulator of synaptic function. |
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| Keywords: | peptide histidine isoleucine synaptosomes rat brain |
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