| GM1对脊髓损伤后神经细胞凋亡的影响 |
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| 引用本文： | 卓豫,廖维宏,吴宝明,王禾,陈韬. GM1对脊髓损伤后神经细胞凋亡的影响[J]. 中国脊柱脊髓杂志, 2003, 13(9): 536-538,i001 |
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| 作者姓名： | 卓豫 廖维宏 吴宝明 王禾 陈韬 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所五室,400042,重庆市 |
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| 摘 要： | 目的:观察神经节苷脂(ganglioside,GM1)对脊髓损伤后神经细胞凋亡的影响。方法:中度脊髓损伤大鼠随机分为对照组及治疗组,在蛛网膜下腔注射生理盐水或神经节苷脂,采用原位末端标记检测凋亡细胞DNA(TUNEL)、流式细胞仪磷脂结合蛋白V/碘化丙啶(AnnexinV/PI)双标检测凋亡细胞及荧光酶联测定法测定半胱氨酸天冬氨酸酶3(Caspase3)的活性。结果:对照组及治疗组均发现凋亡细胞阳性表达,且均在3d达到高峰,但GM1治疗组阳性表达显著低于对照组(P<0.05)。结论:神经节苷脂有阻断神经细胞凋亡的作用,对损伤脊髓组织有明显保护作用。
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| 关 键 词： | GM1 脊髓损伤 神经细胞 细胞凋亡 神经节苷脂 治疗 |
| 文章编号： | 1004-406X(2003)-09-0536-03 |
The anti-apoptosis effect of Ganglioside(GM1) after the spinal cord injury |
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| ZHUO Yu,LIAO Weihong,WU Baoming,et al[Author''s address]Department Five,Research Institute of Surgery,Daping Hospital,The Third Military Medical University,Chongqing,China[. The anti-apoptosis effect of Ganglioside(GM1) after the spinal cord injury[J]. Chinese Journal of Spine and Spinal Cord, 2003, 13(9): 536-538,i001 |
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| Authors: | ZHUO Yu LIAO Weihong WU Baoming et al[Author''s address]Department Five Research Institute of Surgery Daping Hospital The Third Military Medical University Chongqing China[ |
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| Affiliation: | ZHUO Yu,LIAO Weihong,WU Baoming,et al[Author's address]Department Five,Research Institute of Surgery,Daping Hospital,The Third Military Medical University,Chongqing,400042,China[ |
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| Abstract: | |
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| Keywords: | Spinal cord injury Apoptosis Ganglioside |
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