Performance of FDG PET/CT at initial diagnosis in a rare lymphoma: nodular lymphocyte-predominant Hodgkin lymphoma |
| |
Authors: | Jean François Grellier Laetitia Vercellino Thierry Leblanc Pascal Merlet Catherine Thieblemont Pierre Weinmann Marie-Elisabeth Toubert Nathalie Berenger Josette Brière Pauline Brice |
| |
Institution: | 1. AP-HP- H?pital Européen Georges Pompidou, Service de médecine nucléaire, Paris, 75015, France 2. AP-HP- H?pital Saint-Louis, Service de médecine nucléaire, Paris, 75010, France 3. H?pital Saint-Louis, Service d’immuno-hématologie, Paris, 75010, France 4. AP-HP- H?pital Saint-Louis, Service d’hémato-Oncologie, Université Paris Diderot, Sorbonne Paris Cité – INSERM UMR_S1165, Paris, 75010, France 5. AP-HP- H?pital Saint-Louis, Service de pathologie, Paris, 75010, France 6. AP-HP- H?pital Saint-Louis, Service d’hémato-Oncologie, Paris, 75010, France
|
| |
Abstract: | Purpose Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare Hodgkin lymphoma distinguished from classical Hodgkin lymphoma (cHL) by the nature of the neoplastic cells which express B-cell markers. We wanted to determine the diagnostic performance of FDG PET/CT in initial assessment and its therapeutic impact on staging. Methods We retrospectively studied a population of 35 patients with NLPHL (8 previously treated for NLHPL, 27 untreated). All patients underwent an initial staging by pretherapeutic FDG PET/CT. The impact on initial stage or relapse stage was assessed by an independent physician. Results In a per-patient analysis, the sensitivity of the pretherapeutic FDG PET/CT was 100 %. In a per-site analysis, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of pretherapeutic FDG PET/CT were 100 %, 99 %, 97 %, 100 % and 99 %, respectively. Pretherapeutic FDG PET/CT led to a change in the initial stage/relapse stage in 12 of the 35 patients (34 %). In contrast to previous results established without FDG PET/CT, 20 % of patient had osteomedullary lesions. Conclusion Pretherapeutic FDG PET/CT has excellent performance for initial staging or relapse staging of NLPHL. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|