| 胰高血糖素样多肽1和2型糖尿病 |
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| 引用本文： | 兰珍,李彩萍.胰高血糖素样多肽1和2型糖尿病[J].医学综述,2008,14(5):714-716. |
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| 作者姓名： | 兰珍 李彩萍 |
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| 作者单位： | 内蒙古医学院附属医院内分泌科,呼和浩特,010050 |
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| 基金项目： | 内蒙古医学院重大青年基金科研项目 |
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| 摘 要： | 胰高血糖素样多肽1(GLP-1)是由胰腺浕细胞、肠道L细胞分泌的一种胃肠道激素。GLP能促进胰岛素分泌,抑制胰高血糖素的释放,延迟胃排空,增加胰岛?细胞数量,以维持正常血糖,可作为2型糖尿病治疗的新药物。其可被二肽基肽酶Ⅳ降解,半衰期极短,限制了其临床应用,目前研究GLP-1类似物及二肽基肽酶Ⅳ抑制剂有更好的应用前景。本文就GLP-1的作用机制及其在2型糖尿病中的治疗前景进行综述。
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| 关 键 词： | 胰高血糖素样多肽1 2型糖尿病 治疗 |
| 文章编号： | 1006-2084（2008）05-0714-03 |
| 收稿时间： | 2007-09-24 |
| 修稿时间： | 2008-02-05 |
Glucagon-like Peptide-1 and Type 2 Diabetes Mellitus |
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| LAN Zhen,LI Cai-ping.Glucagon-like Peptide-1 and Type 2 Diabetes Mellitus[J].Medical Recapitulate,2008,14(5):714-716. |
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| Authors: | LAN Zhen LI Cai-ping |
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| Institution: | LAN Zhen,LI Cai-ping.(Department of Endocrinology,the Affiliated Hospital of Inner Mongolia Medical Collage,Huhhot 010050,China) |
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| Abstract: | Glucagon-like peptide-1 （Glp-1）was demonstrated to be secreted by a-cells in pancreas and the L-cells in intestine,which has been reported to promote insulin secretion,inhibit gtucagon release,delay gastric emptying, increase the number of islet beta cells and normalizes blood Glucose. As a new therapeutic drug for type 2 diabetes with a very short half-life, GLP-1 was regarded to be degraded by Dipeptidy peptidase-Ⅳ ,which was limited in clinical application.Analogues of GLP-1 and Dipeptidy peptidase-Ⅳ inhibitors have a better prospect in the recent study.This article reviewed the mechanism of GLP-1 and its prospects in treatment of type 2 diabete mellitus. |
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| Keywords: | Glucagon-like peptide-1 Type 2 Diabetes Mellitus Therapy |
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