CCL5引发的新思考:神经病理性疼痛的致病因子？

神经病理性疼痛形成机制极其复杂,尽管近年来人们对病理性疼痛的发病机制及新药开发做了很多研究,但对神经病理性疼痛的形成仍存在疑问。CCL5属于CC亚家族趋化因子,病理状态下对炎症反应的异常调节可诱发或加剧多种疾病。许多研究提示CC亚家族趋化因子CCL5或与病理性疼痛相关,在介导神经病理性疼痛中具有潜在的功能,但其机制尚不十分明确。本文通过综述CCL5在病理性疼痛的产生与调控中的作用机制,探讨CCL5作为神经病理性疼痛致病因子的可能性。

CCL5 triggers new thinking on neuropathic pain

The mechanism of neuropathic pain is extremely complex. Despite of great research efforts on the pathogenesis of neuropathic pain and development of new drugs in recent years, the mechanism of neuropathic pain remains unclear. CCL5 belongs to the C-C chemokine subfamily, and its abnormal regulation of inflammatory responses under pathological condition may induce or exacerbate a variety of diseases. Recently, many researches have suggested that CCL5 has the potential of mediating neuropathic pain, but with unknown mechanism. This paper reviewed the role of CCL5 in the development and regulation of neuropathic pain and discussed the possibility of CCL5 as an cause of neuropathic pain.