多单元胃漂浮给药系统研究进展

胃漂浮给药系统可以增加药物在胃中的滞留时间，从而增加药物的吸收，提高药物的生物利用度。按药物剂量的分配方式，胃漂浮给药系统可分为“一单元”和“多单元”给药系统（如微丸、微球等）。“多单元”较“一单元”胃漂浮给药系统有着药物释放吸收的个体差异小、可避免药物剂量的“全或无”现象、对胃刺激性小、可以将不同释放速率的药物单元组合等优点。本文介绍了目前国内外多单元胃漂浮给药系统的类型、制备方法、释药情况及其体内漂浮性能的研究方法。

A multiple-unit floating drug delivery system: research progress

The floating drug delivery system (FDDS) can prolong gastric residence time (GRT), resulting in increased absorption of the drug and high bioavailability. FDDS can be divided into two forms: single-unit system and multiple-unit system (e.g. pellet, microsphere etc.). From them, the multiple-unit formulations show several advantages over the single-unit ones: smaller individual differences, avoidance of ‘all or nothing’ gastric emptying, smaller irritant effect of weakly acidic drugs on the stomach and co-administration of units with different release profiles. This article gives a review of preparation, drug release and in vivo study of the floating ability of different multiple-unit FDDS.