双管同步换血治疗新生儿高胆红素血症对机体内环境的影响

目的探讨双管同步换血治疗新生儿高胆红素血症对机体内环境的影。方法回顾性分析重庆儿童医院新生儿科136例高胆红素血症新生儿经外周动静脉双管同步换治疗的临床资料,比较换血前后血清胆红素、生化、血常规的变化。结果换血后血清胆红素明显下降（P〈0.01）,同时,血清钾、钠、氯、钙离子、血小板、白细胞、碳酸氢根浓度均由不同程度下降（P〈0.01）;血糖、血清磷有升高（P〈0.01）;血红蛋白、pH则在换血前后无明显变化（P〉0.05）。结论外周双管同步换血治疗新生儿高胆红素血症有显著疗效,对内环境有一定影响,但这些影响不对机体构成严重危险。

Effection of exchange transfusion on the internal environment homeostasis of neonates with hyperhillirubinemia

Objective To study the effect of exchange transfusion on the internal environment homeostasis of neonates with hyperhillirubinemia.Methods The clinical data of 136 examples of neonates with hyperhillirubinemia in hospital was retrospectively analyzed.All neonates were treated by peripheral arteriovenous simultaneous exchange transfusion with the standard of exchange transfusion.The data of serum bilirubin,biochemistryf,ull blood examination before and after the exchange transfusion were compared.Results the serum bilirubin was dramaticly decreased after exchange transfusion when comparied with before exchange transfusion（P〈0.01）.the concentration of serum kalium,natrium,chlorine,calcium,blood platelet,white blood cell and bicarbonate radical were decreased significantly after exchange transfusion（P〈0.01）,the concentration of serum glucose and phosphorus were increased obviously after replacement transfusion（P〈0.01）.No significant differernce of hemoglobin and pH was observed before and after exchange transfusion（P〉0.05）.Conclusions Synchronizing replacement transfusion of peripheral blood was effective treatment for neonate with hyperhillirubinemia,which had a mild side effect on internal environment homeostasis.