Ectodysplasin-1 deficiency in a German Holstein bull associated with loss of respiratory mucous glands and chronic rhinotracheitis |
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Authors: | Seeliger F Drögemüller C Tegtmeier P Baumgärtner W Distl O Leeb T |
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Institution: | Departments of Pathology, School of Veterinary Medicine, Bünteweg 17p, 30559 Hannover, Germany. |
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Abstract: | A 2-year-old German Holstein bull was identified as a carrier of a mutation within the X-chromosomal ED1 gene, which encodes a TNF-related signalling molecule mainly involved in ectodermal development. The clinicopathological appearance was associated with hypotrichosis, hypodontia, and a reduced number of eccrine glands, in addition to chronic rhinotracheitis and partial squamous metaplasia. Furthermore, for the first time in an ED1-deficient animal, a complete lack of respiratory mucous glands was observed. This suggests that the ED1 gene plays a role in the development of mucous glands, the absence of which resembles a feature of X-linked anhidrotic ectodermal dysplasia (ED1) in human patients. |
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Keywords: | cattle ectodysplasin-1 ED1 genetic disease respiratory glands rhinotracheitis |
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