Increased mRNA levels of the mitochondrial complex I 75-kDa subunit |
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Authors: | Claudia Mehler-Wex MD J Catharina Duvigneau Romana T Hartl Dorit Ben-Shachar Andreas Warnke Manfred Gerlach |
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Institution: | Dept. of Child and Adolescent Psychiatry, University of Würzburg, Füchsleinstr. 15, 97080 Würzburg, Germany. mehler@kjp.uni-wuerzburg.de |
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Abstract: | Recently, the dopamine D3-receptor mRNA on blood lymphocytes and platelet mitochondrial complex I were suggested as biological markers of schizophrenia in adults. We investigated the mRNA level of the dopamine D3-receptor and complex I subunits in whole blood cells of early-onset schizophrenic patients compared to healthy controls using quantitative real-time PCR. We found an increased mRNA expression of the complex I 75-kDa subunit (referred to beta-actin in schizophrenic patients (0.57 +/- 0.24 versus 0.23 +/- 0.18 in controls, P < 0.01)), but were unable to analyse the dopamine D3-mRNA expression. This increase appears to be inherent to schizophrenia, because it was found in neuroleptic-naive patients and it was not affected by neuroleptic treatment. Our preliminary findings suggest the mitochondrial complex I as a potential peripheral marker of schizophrenia and its involvement in the pathophysiology of this illness. |
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