局部亚低温治疗对急性脑出血患者血浆脑钠肽的影响

目的研究局部亚低温治疗对急性脑出血患者血浆脑钠肽的影响。方法将60例急性脑出血患者按照随机数字表法分为局部亚低温组（30例）和常规治疗组（30例），常规治疗组给予常规治疗，局部亚低温组在常规治疗的基础上加用局部亚低温治疗。在入院当天和治疗第3，7，14天采用美国国立卫生研究院卒中量表（NIHSS）评价神经功能缺损情况，在入院当天和治疗第3，14天检测血浆脑钠肽；治疗第14天判断疗效。结果两组入院当天血浆脑钠肽比较差异无统计学意义（P〉0．05），局部亚低温组治疗第3，14天血浆脑钠肽明显低于常规治疗组（153．47±32．01）ng／L比（187．45±40．21）n矶和（111．02±38．27）ng／L比（139．71±29．53）ng／L]，差异有统计学意义（P〈0．01或〈0．05）。两组入院当天和治疗第3天NIHSS评分比较差异无统计学意义（尸〉0．05），局部亚低温组治疗第7，14天NIHSS评分明显低于常规治疗组（13．84．4±6．00）分比（16．59±4．62）分和（9．23±4．48）分比（13．02±6．76）分]，差异有统计学意义（P〈0．01）。局部亚低温组总有效率明显高于常规治疗组90．0％（27／30）比66．7％（20／30）]，差异有统计学意义（P〈0．05）。结论局部亚低温治疗可显著改善急性脑出血患者神经功能缺损情况，并降低血浆脑钠肽浓度，提高疗效。

Effect of local mild hypothermia on serum brain natriuretic peptide in patients with acute intracerebral hemorrhage

Objective To study the effect of local mild hypothermia on serum brain natriuretic peptide （BNP） in patients with acute intracerebral hemorrhage. Methods Sixty patients with acute intracerebral hemorrhage were divided into local mild hypothermia group （30 cases） and routine therapy group （ 30 cases ） by random digits table method. Routine therapy group was given conventional therapy, and local mild hypothermia group was given local mild hypothermia treatment besides conventional therapy. The neurologic impairment was evaluated according to American National Institute of Health Stroke Scale （NIHSS） scores on admission, and on the 3rd, 7th and 14th day after treatment. Serum BNP levels in patients were determined dynamically on admission,and on the 3rd and 14th day after treatment. The effect was evaluated on the 14th day after treatment. Results There was no significant difference in serum BNP on admission between two groups （P 〉0.05）. Serum BNP on the 3rd,14th day after treatment in local mild hypothermia group was lower than that in routine therapy group （ 153.47±32.01 ） ng/L vs. （ 187.45 ± 40.21 ） ng/L and （ 111.02 ± 38.27 ） ng/L vs.（ 139.71 ± 29.53 ） ng/L], and there was significant differenee（P 〈 0.01 or 〈 0.05 ±. There was no significant difference in NIHSS scores on admission and on the 3rd day after treatment between two groups （P 〉0.05）. NIHSS scores on the 7th and 14th day after treatment in local mild hypothermia group was lower than that in routine therapy group （ 13.84 ± 6.00） scores vs. （ 16.59 ± 4.62） scores and （9.23 ± 4.48） scores vs. （ 13.02 ± 6.76） scores], and there was significant difference（P 〈 0.01 ）. The total effective power in local mild hypothermia group was higher than that in routine therapy group90.0% （27/30） vs. 66.7%（20/30） ],and there was significant difference（P〈 0.05）. Conclusions The local mild hypothermia therapy can not only significantly improve the defect of nerve function in patients with acute intracerebral hemorrhage but also reduce the serum BNP. It can improve the curative effect in patients with acute intracerebral hemorrhage.