630例乳腺癌术后手术部位感染的相关因素分析

目的探讨乳腺癌术后手术部位感染（SSI）的影响因素，为制定SSI的控制措施提供依据。方法回顾性分析630例乳腺癌患者的临床资料，观察乳腺癌术后SSI发生率，并对其常见的临床、病理相关危险因素进行单因素和多因素Logistic回归分析。结果乳腺癌术后SSI发生率为3．65％（23／630），金黄色葡萄球菌是SSI的主要病原菌（14／20）。单因素分析显示：化疗相关粒细胞减少症、糖尿病、引流管留置时间为乳腺癌术后SSI危险因素（P〈0．05）。多因素Logistic回归分析显示：化疗相关粒细胞减少症、引流管留置时间是乳腺癌术后SSI的独立危险因素（P〈0．05）。结论化疗相关粒细胞减少症、引流管留置时间是乳腺癌术后SSI发生的主要因素，必须采取相对应的综合性措施才能有效地降低乳腺癌术后SSI发生率。

Risk factors for surgical site infection in 630 patients with breast cancer

Objective To investigate the risk factors associated with surgical site infection （SSI） in patients with breast cancer, and provide the basis for preventing SSI. Methods Case-control study was used to investigate the clinical data of 630 patients of breast cancer retrospectively by single factor and multiple factors regressive analysis. Results The incidence rate of SSI was 3.65% （23/630）,the main pathogenic bacteria was staphylococcus aureus （14/20）, single factor regressive analysis showed that granulocytopenia associated with chemotherapy,diabetes mellitus, time of drainage were the risk factors of SSI （P 〈 0.05）. Multiple factors regressive analysis showed that granulocytopenia associated with chemotherapy, time of drainage were the independent risk factors of SSI （P 〈 0.05）. Conclusion Granulocytopenia associated with chemotherapy, time of drainage are the independent risk factors of SSI and comprehensive preventive measures should be taken to control the incidence rate of SSI.