α-硫辛酸联合甲钻胺治疗糖尿病外周神经病变的效果观察

目的评价应用α-硫辛酸联合甲钴胺治疗糖尿病外周神经病变的临床效果。方法选取糖尿病外周神经病变患者90例，按随机数字表法分为两组，每组45例，观察组给予α-硫辛酸联合甲钴胺治疗，对照组给予α-硫辛酸治疗，经过3周的药物治疗后观察患者的临床表现与肌电图情况，并进行分析比较。结果观察组的总有效率显著高于对照组93．3％（42／45）比55．6％（25／45）]，差异有统计学意义（P〈0．05）；观察组患者的腓总神经感觉传导速度治疗后显著高于对照组（49．5±3．2）m／s比（40．2±2．9）m／s]，差异有统计学意义（P〈0．05）；正中神经感觉传导速度，正中神经和腓总神经运动传导速度比较差异无统计学意义（P〉0．05）。在药物治疗期间和治疗后，患者均未出现不良反应。结论利用α-硫辛酸联合甲钻胺治疗糖尿病外周神经病变患者，可有效改善患者的临床症状，具有较好的临床效果。

Effect of alpha thioctic acid combined with mecobalamin in patients with diabetic peripheral neuropathy

Objective To evaluate the effect of alpha thioctic acid combined with mecobalamin in patients with diabetic peripheral neuropathy. Methods Ninety patients with diabetic peripheral neuropathy were divided into observation group and control group by random digits table method with 45 cases each. Thepatients in observation group received alpha thioctic acid combined with mecobalamin treatment, and patients in control group received alpha thioctic acid treatment only. All patients were treated for 3 weeks. The clinical manifestation and electromyography effects were observed and compared after treatment. Results The total effective rate in observation group was significantly higher than that in control group 93.3% （42/45） vs. 55.6%（25/45 ） ], and there was statistical difference （P 〈 0.05）. The sensory conduction velocity of common peroneal nerve after treatment in observation group was significantly higher than that in control group （49.5 ±3.2） m/s vs. （40.2 ±2.9） m/s],and there was statistical difference （P 〈0.05）. The sensory conduction velocity of median nerve,the motor conduction velocity of median nerve and common peroneal nerve had no significant differences between two groups （P 〉 0.05）. No adverse reaction happened during and after treatment. Conclusion Alpha thioctic acid combined with mecobalamin may improve the clinical efficacy of patients with diabetic peripheral neuropathy.