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Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells
Authors:H Wang  M Iezzi  S Theander  P A Antinozzi  B R Gauthier  P A Halban  C B Wollheim
Institution:(1) Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland;(2) Department of Medical Genetics and Development, University Medical Center, Geneva, Switzerland
Abstract:
Keywords:Beta cell  cAMP  FGFR1  GLP-1 receptor  IPF-1  MODY4  Pdx-1  Prohormone convertase-1
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