Bone mineralization and metabolism of3H-25-hydroxyvitamin D3 in thyroparathyroidectomized rats treated with parathyroid extract |
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| Authors: | J. I. Rader G. A. Howard E. Feist R. T. Turner D. J. Baylink |
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| Affiliation: | (1) Department of Medicine, University of Washington School of Medicine, Seattle, Washington;(2) Veterans Administration Medical Center, American Lake, 98493 Tacoma, Washington, USA;(3) Dept of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, 53706 Madison, Wisconsin, USA |
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| Abstract: | Summary Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid maturation. Significant decreases in osteoid width and mineralizing front width, as well as a 60% increase in the rate of initial mineralization were observed in the PTE-treated group. Conversion of3H-25-hydroxyvitamin D3 to3H-1,25-dihydroxyvitamin D3 was 4-fold higher in the PTE-treated group than in the untreated animals. Increased formation of 1,25-dihydroxyvitamin D3 in response to treatment with PTE may play a major role in correcting the mineralizing defect resulting from thyroparathyroidectomy. |
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| Keywords: | Mineral metabolism Parathyroid extract Thyroparathyroidectomy 25-Hydroxyvitamin D3 1,25-Dihydroxyvitamin D3 |
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