Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease |
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Authors: | Morris C R Kuypers F A Larkin S Sweeters N Simon J Vichinsky E P Styles L A |
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Affiliation: | Department of Emergency Medicine, Children's Hospital Oakland, CA 94609, USA. johnclaud@home.com |
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Abstract: | To determine the effects of L-arginine (L-Arg) supplementation on nitric oxide metabolite (NOx) production, oral L-Arg was given to normal controls, sickle cell disease (SCD) patients at steady state and SCD patients hospitalized with a vaso-occlusive crisis (VOC). L-Arg (0.1 g/kg) increased NOx formation by 18.8 +/- 68% in normal controls, whereas steady-state SCD patients demonstrated a paradoxical decrease in NOx of -16.7 +/- 4% (P = 0.004). In contrast, patients with VOC demonstrated a dramatic increase in NOx production by +77.7 +/- 103%, a response that was dose dependent. L-Arg appears to be the rate-limiting step in NOx production during VOC. Oral arginine may therefore benefit SCD patients by inducing an increase in NO production during VOC. |
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Keywords: | nitric oxide l-arginine sickle cell disease vaso-occlusive crisis nitric oxide metabolites |
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