Anticoagulant and antithrombotic properties of synthetic sulfated bis-lactobionic acid amides |
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Authors: | W. Raake R. J. Klauser H. Elling E. Meinetsberger |
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Affiliation: | Division “Research and Development” Luitpold-Werk, Zielstattstraβe 9, D-8000, München 70, FRG |
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Abstract: | Sulfated bis-lactobionic acid amides, a new class of polyanions with heparin-like properties, were synthesized and their antithrombotic and anticoagulant activities were determined. Compared to heparin and FragminR, a low molecular weight heparin, the substances exhibited moderate to low anticoagulant activities in aPTT, thrombin clotting time and Heptest assays. In amidolytic assays no anti-Ila activity and only exceedingly low anti-Xa activity was observed. The antithrombotic activity of the bis-lactobionic acid amides was determined using two thrombosis models. In rabbit and rat models thrombi were induced by a combination of endothelial damage and reduction of blood flow or only by endothelial damage. At least one of the bis-lactobionic acid amides (LW 10082) exhibited a considerable antithrombotic activity which was similar to low molecular weight heparin. |
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Keywords: | Author Keywords: Bis-lactobionic acid amides coagulation antithrombotic thrombosis |
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