Demyelinating canine distemper encephalomyelitis: measurement of myelin basic protein in cerebrospinal fluid |
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| Authors: | B.A. Summers J.N. Whitaker M.J.G. Appel |
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| Affiliation: | 1. The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia;2. Mabritec SA, Riehen, Switzerland;3. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia;4. King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia;5. World Health Organization Collaborating Centre for Infection Prevention and Control, Riyadh, Saudi Arabia.;1. Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA;2. Texas A&M Energy Institute, Texas A&M University, College Station, TX 77843, USA;3. Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA;4. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA |
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| Abstract: | Beagle dogs were experimentally infected with the Cornell A75-17 strain of canine distemper virus. At three time points post-infection (PI), immunoreactive myelin basic protein (MBP) was measured in cerebrospinal fluid (CSF). Levels were correlated with neuropathological findings, interferon in CSF and virus isolation from the brain. CSF from animals inoculated with Cornell A75-17 strain often showed detectable immunoreactive MBP late in the disease course. As anticipated from earlier morphological studies, CSF drawn around day 20 PI lacked MBP while subsequent samples were positive. Dogs with severe demyelination had elevated values of immunoreactive MBP while dogs with only mild inflammation had little or none. Release of MBP or MBP peptides into CSF of dogs with canine distemper may be a valuable laboratory test in studies of the natural history of this disease and in assessing the response to treatment. Whether an immune response to MBP plays an immunopathogenic role in the chronic, demyelinating phase of canine distemper encephalitis remains to be determined. |
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| Keywords: | Canine distemper virus Myelin basic protein Cerebrospinal fluid Demyelination |
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