| 聚乙二醇修饰脂质体的ABC现象研究进展 |
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| 作者姓名： | Xu H Wang KQ Huang WW Deng YH Chen DW |
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| 作者单位： | 辽宁师范大学化学化工学院;沈阳药科大学药学院; |
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| 摘 要： | 通常聚乙二醇(polyethylene glycol,PEG)修饰脂质体被认为几乎没有或仅有很低的免疫原性。最新的文献报道,重复注射PEG修饰脂质体发生了免疫反应。当向同一动物体内重复注射(间隔几天)PEG化脂质体时,二次注射的PEG化脂质体导致体内循环时间降低,于肝和脾的聚集量增加,这种现象称为加速血液清除(accelerated blood clearance,ABC)现象。该免疫反应使PEG化制剂的发展和临床应用面临严峻的挑战,可能造成药物或基因治疗效率的下降,甚至引起临床的毒副作用。本文综述了ABC现象的定义、验证ABC现象的方法和手段、ABC现象成因的研究进展及影响因素,并对其他PEG修饰载体是否也会发生ABC现象进行了探讨。
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| 关 键 词： | 聚乙二醇 脂质体 加速血液清除 抗-聚乙二醇免疫球蛋白M |
Recent advances in the study of accelerated blood clearance phenomenon of PEGylated liposomes |
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| Xu H,Wang KQ,Huang WW,Deng YH,Chen DW.Recent advances in the study of accelerated blood clearance phenomenon of PEGylated liposomes[J].Acta Pharmaceutica Sinica,2010,45(6):677-683. |
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| Authors: | Xu Huan Wang Kai-Qian Huang Wei-Wei Deng Yi-Hui Chen Da-Wei |
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| Institution: | XU Huan1,WANG Kai-qian2,HUANG Wei-wei2,DENG Yi-hui2,CHEN Da-wei2(1.College of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian 116029,China,2.China School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | It is generally believed that liposomes modified with polyethylene glycol(PEG) have no or lower immunogenicity.However,based on many recent literatures,when the PEGylated liposomes were repeatedly applied to the same animal,the immune responses occurred.The first injection of PEGylated liposomes resulted in a reduction in the circulation time and an increase in hepatic and splenic accumulation of the second dose of PEGylated liposomes in a time-interval,which was called accelerated blood clearance(ABC) phen... |
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| Keywords: | polyethylene glycol liposome accelerated blood clearance anti-polyethylene glycol IgM |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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