| 蛋白激酶C在心肌纤维化中的作用 |
| |
| 引用本文： | 王立英,杨世杰.蛋白激酶C在心肌纤维化中的作用[J].药学学报,2010(12). |
| |
| 作者姓名： | 王立英 杨世杰 |
| |
| 作者单位： | 吉林大学白求恩医学院药理学教研室; |
| |
| 基金项目： | 国家重点基础研究发展计划(973计划)资助项目(2007CB512006); 国家自然科学基金资助项目(30873066,30472020,30672654) |
| |
| 摘 要： | 心肌纤维化是多种心脏疾病发展的共同结果,心肌成纤维细胞的增殖导致细胞外基质蛋白代谢紊乱,引起心肌重塑,最终导致恶性心律失常、心功能衰竭、甚至心脏性猝死的发生。有效地抑制心肌重塑可预防猝死的发生。明确蛋白激酶C(protein kinase C,PKC)对心肌纤维化的调控机制,可能为逆转心肌重塑提供新的治疗靶点。
|
| 关 键 词： | 蛋白激酶C 心肌成纤维细胞 心肌纤维化 心肌重塑 基质金属蛋白酶 |
The function of protein kinase C in myocardial fibrosis |
| |
| WANG Li-ying,YANG Shi-jie.The function of protein kinase C in myocardial fibrosis[J].Acta Pharmaceutica Sinica,2010(12). |
| |
| Authors: | WANG Li-ying YANG Shi-jie |
| |
| Institution: | WANG Li-ying,YANG Shi-jie*(Department of Pharmacology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,China) |
| |
| Abstract: | Myocardial fibrosis is the common results of the development of a variety of heart diseases which leads to extracellular matrix protein metabolic disorders and causes cardiac remodeling owing to cardiac fibroblasts proliferation,eventually results in malignant arrhythmia,heart failure,and even the occurrence of sudden cardiac death.Effective inhibition of myocardial remodeling could prevent the occurrence of sudden death.To know the protein kinase C(PKC) effective mechanism of regulation on myocardial fibro... |
| |
| Keywords: | protein kinase C cardiac fibroblast myocardial fibrosis cardiac remodeling matrix metallo-proteinase |
| 本文献已被 CNKI 等数据库收录！ |
