Age-dependence of the spontaneous activity of the rat urinary bladder |
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Authors: | Email author" target="_blank">Gyula?P?SZIGETIEmail author George?T?SOMOGYI László?CSERNOCH Enik??A?SZéLL |
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Institution: | (1) Department of Physiology, Medical-, Health- and Science Centre, University of Debrecen, Nagyerdei krt. 98, H-4012 Debrecen, Hungary;(2) Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA;(3) Department of Pediatrics, University of Debrecen, Debrecen, Hungary |
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Abstract: | Abnormal mechanical function of the bladder is manifested in a number of ways including higher frequency of involuntary detrusor
contractions associated with reduced compliance of the bladder that is responsible for an increase in intraluminal pressure
during filling. There are basically two ways to approach experimentally these problems: (1) by studying the neural control
of the lower urinary tract function, and (2) by measuring the properties of smooth muscle cells in the bladder wall. Studies
on smooth muscle function often do not take the origin of smooth muscle cells into account i.e., whether they were harvested
from normal or overactive bladders. Although, this simplistic view may be beneficial to understanding the generation of the
spontaneous activity of the bladder, however, it does not sufficiently explain the cell-to-cell propagation of the spontaneous
smooth muscle activity. The spontaneous activity of smooth muscle is an important factor that works against the bladder compliance
in the filling phase, and may inversely affect the neurally evoked response during micturition. The intensity of spontaneous
activity is the age-dependent; it is high in neonatal bladders it is small or almost non-existent in adults and reemerges
in older bladders. This review focuses on these age-dependent alterations of spontaneous bladder contractions and describes
the possible mechanisms which may have important role in regulating the spontaneous contractions using the rat as an animal
model. |
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