| 脐血巨核系造血祖细胞的初步研究 |
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| 引用本文： | 侯怀水,沈柏均,张洪泉,时庆,隋星卫,王正起.脐血巨核系造血祖细胞的初步研究[J].现代妇产科进展,1995(3). |
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| 作者姓名： | 侯怀水 沈柏均 张洪泉 时庆 隋星卫 王正起 |
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| 作者单位： | 山东医科大学附属医院 |
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| 摘 要： | 用甲基纤维素法培养１５例新生儿脐血巨核系造血祖细胞（ＣＦＵ－Ｍｅｇ），观察了ＣＦＵ－Ｍｅｇ的生长特性、集落产率与接种细胞数的相关性，并与成人骨髓及外周血ＣＦＵ－Ｍｅｇ的数量进行了比较。结果表明，脐血中富含ＣＦＵ－Ｍｅｇ，且分裂快、子代细胞多，形成集落早呈现活跃的增殖状态，其数量低于成人骨髓但个体间差异明显，２６．７％的样本ＣＦＵ－Ｍｅｇ产率高于骨髓。接种细胞数量与ＣＦＵ－Ｍｅｇ的产率在一定范围内呈良好的线性关系。
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| 关 键 词： | 脐血，巨核细胞系造血祖细胞 |
Study of megakaryocyte progenitors (CFU-Meg) in human umbilical cord blood |
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| .Hou Huaishul,Shen Baijun, Zhang Hongquan,et al.Study of megakaryocyte progenitors (CFU-Meg) in human umbilical cord blood[J].Current Advances In Obstetrics and Gynecology,1995(3). |
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| Authors: | Hou Huaishul Shen Baijun Zhang Hongquan |
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| Abstract: | The characterization of umbilicai cord blood megakaryocyte progenitor cells was investigated by the method of methylcellulose cultures. The results showed that human umbilical cord blood contained a high level of megakaryocyte progenitor colls (CFUMeg), they were in a state of active proliferation and could develop into colonies early;morever, the colonies formed were large in size, with more progeny cells in each colony.The average concentration of CFU-Meg in umbilical cord blood is lower than that of bone marrow, but the colony yield was much different within the umbilical cord blood samples, 26.7% of them had a higher yield of CFU-Meg than the average bone marrow yield. |
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| Keywords: | Umbilical cord blood CFU-Meg |
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