CT灌注诊断腮腺肿瘤的临床价值评价

目的:评价CT灌注方法对腮腺肿瘤的诊断价值。方法:51例(53侧:良性肿瘤35侧;恶性肿瘤18侧)经术后病理证实的腮腺肿瘤于术前行CT灌注检查。CT灌注的评价指标包括以下参数:血流量(blood flow,BF)、血容量(blood volume,BV)、平均通过时间(mean transmit time,MTT)和表面通透性(permeability surface,PS)。采用非参数检验中的Wilcoxon符号检验进行统计学处理。结果:腮腺良性肿瘤的CT灌注参数分别为BF:(139.85±175.13)ml·100g-1·min-1;BV:(17.16±15.67)ml·100g-1;MTT:(13.27±4.42)s;PS:(24.38±14.52)ml·100g-1·min-1。腮腺恶性肿瘤的CT灌注参数分别为BF:(231.69±205.29)ml·100g-1·min-1;BV:(32.22±20.56)ml·100g-1;MTT:(11.40±3.95)s;PS:(38.28±19.00)ml·100g-1·min-1。统计结果显示:CT灌注参数BF、BV和PS的平均值在腮腺良性肿瘤和恶性肿瘤之间具有显著差异(P<0.01);而CT灌注参数MTT的平均值在两者之间无显著差异(P>0.05)。结论:CT灌注检查方法对腮腺良性肿瘤和恶性肿瘤的鉴别诊断具有一定价值。

Diagnostic value of CT perfusion for parotid gland tumors

PURPOSE: The aim of this study was to determine whether CT perfusion was valuable in differentiating benign tumors from malignant ones in the parotid gland. METHODS: Fifty-three parotid gland tumors, 35 benign and 18 malignant, in 51 patients were included in this study. All the tumors were confirmed histopathologically and examined with CT perfusion before operations. The parameters of CT perfusion, including blood flow (BF: ml x 100g(-1) x min(-1)), blood volume (BV: ml x 100g(-1)), mean transmit time (MTT:s) and permeability surface (PS: ml x 100g(-1) x min(-1)) were evaluated. Wilcoxon sign sum test, a nonparameters test for paired data were used to determine the statistical differences of parameters between the benign and malignant tumors. RESULTS: The mean values +/- standard variations of BF, BV, MTT and PS were 139.85+/-175.13, 17.16+/-15.67, 13.27+/-4.42, and 24.38+/-14.52 respectively in benign tumors, versus 231.69+/-205.29, 32.22+/-20.56, 11.40+/-3.95 and 38.28+/-19.00 respectively in malignant tumors. Except for MTT, the differences of BF, BV and PS between benign and malignant tumors were statistically significant (P<0.01). CONCLUSIONS: On the basis of the results of this study, the parameters of CT perfusion, BF, BV and PS, were valuable in differentiating benign and malignant tumors of the parotid gland.