格列喹酮联合氨氯地平对高血压病患者动脉弹性的影响

目的探讨格列喹酮联合氨氯地平治疗对高血压合并糖尿病患者动脉弹性和血压的短期影响。方法120例患者被分成四组，高血压和高血糖控制组（双高控制组）30例，高血压控制而血糖未控制组（高血糖组）30例，高血压未控制而血糖控制组（高血压组）30例，高血压和高血糖均未控制组（双高未控制组）30例。另设正常对照组E30例。应用VP-1000动脉硬化分析仪测定受试者臂踝脉搏波传导速度（baPWV）。结果baPWV自正常对照组至双高未控制组，呈逐渐下降趋势，双高未控组明显低于其他四组（P〈0．01），Z,L高未控组、高血压组和高血糖组分别较双高控制组及正常对照组明显下降（P〈0．01），双高未控组也明显低于高血压组和高血糖组（P〈0．01）；双高控制组及正常对照组之间差异无统计学意义（P〉0．05）；在收缩压（SBP）、舒张压（DBP）和脉压（PP）方面，高血压组、高血糖组和双高未控组明显高于双高控制组、对照组（P〈0．01）。baPWV与血压、脉压差和血糖呈正相关，并且与SBP、血糖呈强相关。结论降压降糖联合治疗较单纯降压或降糖更能改善动脉弹性功能，延缓动脉硬化。

Influence of gUquidone and amlodipine maleate on artery elasticity of hypertensive patients

Objective To study the influence of gliquidone and amlodipine maleate on artery elasticity of hypertensive and diabetes mellitus patients. Methods Patients were divided into 4 groups：hypertension and hyperglycemia controlled group（ n = 30 ） , hypertension controlled and hyperglycemia controlled group （ n = 30）, hypertension uncontrolled and hyperglycemia controlled group （ n = 30 ）, hypertension and hyperglycemia uncontrolled group （ n = 30 ）, and in addition normal control group （ n = 30）. Brachial pulse pressure （PP）, brachial -ankle pulse wave velocity （baPWV） were measured before and after treatment. Results The values of baPWV were gradually decline from the normal control group to hypertension and hyperglycemia uncontrolled group, and the value was significantly below in hypertension and hyperglycemia uncontrolled group than those of other four groups （P 〈 0.01 ）. The values of baPWV were dramaticaly declined in hypertension and hyperglycemia uncontrolled group, in hypertension uncontrolled and hyperglycemia controlled group, and in hypertension controlled and hyperglycemia uncontrolled group, than those of hypertension and hyperglycemia controlled group and normal control group （P 〈 0.01 ）. The values of baPWV were declined in hypertension and hyperglycemia uncontrolled group than those of hypertension controlled and hyperglycemia uncontrolled or hypertension uncontrolled and hyperglycemia controlled group （P 〈 0.01 ）. The values of baPWV were no obvious difference in hypertension and hyperglycemia controlled group and normal control （P 〉 0.05 ）. The values of SBP, DBP and PP were significantly higher in hypertension controlled and hyperglycemia uncontrolled group, hypertension uncontrolled and hyperglycemia controlled group, hypertension and hyperglycemia uncontrolled group, than this of hypertension and hyperglycemia controlled group and normal control （P 〈0. 01 ）. The values of baPWV and blood pressure, blood pressure and pulse were positively correlated, the values of baPWV and SBP, and hyperglycemia were strongly correlated. Conclusions Regulate blood press and blood glucose level is more effiective to improve arteries elasticity and slow hardening of its function than pure adjust blood pressure or glucose.