局部亚低温联合依达拉奉治疗急性大面积脑梗死

目的研究局部亚低温联合依迭拉奉治疗急性大面积脑梗死的临床疗效及其对血液超敏c反应蛋白（hs—CRP）水平的影响。方法发病24h内入院的大面积脑梗死患者84例，随机分为观察组和对照组各42谯。两组给予了长达拉奉静脉滴注14a,观察组加用32-34℃的低温治疗72h,两组患者分别于入院的，治疗了a1及14d后进行神经功能缺损评分及临床疗效评定，并测定hs—CRP水平。结果观察组及对照组治疗14d后神经功能缺损评分、hs—CRP水平分别与治疗前比较，差异有统计学意义（P〈0．05）；观察组与对照组治疗7d、14d后的神经功能缺损评分及hs—CRP水平比较，差异有统计学意义（P〈0．05）。结论局部亚低温联合依达拉奉治疗大面积脑梗死能取得更佳疗效，是值得进一步研究并应用于临床的治疗手段。

Local mild hyypothermia combined with edaravene in treatment of acute large area brain infarction

Objective To study the influence mia on the level of high sensitivity C - reactive protein tion brain infarction （massive hemispheric infarction ）, of edaravone combined with local mild hypother- （ hs - CRP） of the patients with anterior circula- and evaluate its clinical efficacy. Methods All 84 patients with massive hemispheric infarction within the first 24 hours from stroke onset were randomly divided into the control group and edaravone combined with hypothermia group （42 patients respectively）. The edaravone combined with local mild hypothermia group was treated with edaravone and the tem- perature was controlled in the range of 32℃ to 34 ℃ for 72 hours, the observation group was only treated with edaravone. In both groups, the determination of hs - CRP and the neurological deficit score scale assessment of prognosis were measured at the time of admission, the seventh day and the forteenth day. Resuits The determination of hs - CRP and the neurological deficit score （NDS） of the two groups after treatment were significantly lower than those before treatment （ P 〈 0.05 ）, the determination of hs - CRP and the neurological deficit score （NDS） of the edaravone with hypothermia group after treating for 14 days were significantly lower than those of the control group （ P 〈 0.05 ）. Conclusions Local mild hypothermia combined with edaravone can help to achieve greater effectiveness for massive cerebral infarction. So it should be worthy to further study.