早期短程应用美洛培南治疗严重烧伤的临床对比研究

目的研究早期短程应用美洛培南对严重烧伤的治疗效果。方法前瞻性地选择特重度以上烧伤患者49名。治疗组21名伤后24h应用美洛培南3～5天。对照组28名，伤后24h应用头孢三、四代抗生素3～5天。观察患者SIRS、创面脓毒血症、MODS发生率，死亡率及治愈好转率。结果治疗组SIRS发生率与对照组比较无差异，创面脓毒血症、MODS发生率及死亡率显著低于对照组，治愈好转率明显高于对照组。结论早期短程应用美洛培南可以减少创面脓毒血症、MODS的发生，降低死亡率，提高严重烧伤患者的治愈好转率，对SIRS的发生率影响不大。

Clinical Research on Early Short-course Application of Meropenem in Treating Severe Burns

Objective To study the curative effect of early short-course application of Meropenem in treating severe burns. Methods 49 cases with severe burns were prospectively selected .21 cases in treatment group were given Meropenem 24 hours after burned for 3 to 5 days.28 cases in control group were given cephalosporins 2d. hours after burned for 3 to 5 days. SIRS, pyohemia on wound surface, the occurrence of MODS, the death rate and the resolving rate were observed. Results The occurrence of SIRS in treatment group was not different from that of control group, pyohemia on wound surface, the occurrence of MODS and the death rate in treatment group were much lower than those in control group,and the resolving rate in treatment group was much higher than that in control group, Conclusion Early short-course application of Meropenem may decrease the occurrence of pyohemia on wound surface and MODS, and lower the death rate ; it can raise the resolving rate of severe burns but show no much influence on the occurrence of SIRS.