卡维地洛联合曲美他嗪辅助治疗慢性充血性心力衰竭疗效观察

目的观察卡维地洛联合曲美他嗪治疗慢性充血性心力衰竭（CHF）的临床疗效。方法选择慢性CHF患者60例，随机分为两组：对照组30例，给予洋地黄制剂、利尿剂、血管扩张剂、血管紧张素转换酶抑制剂（ACEI）等常规药物治疗；治疗组30例，在常规药物治疗基础上加用卡维地洛（2次／d，25mg／次，疗程60d）和曲美他嗪（3次/d，20mg／次，疗程60d）。结果治疗组心功能改善有效率为90．0％，明显高于对照组的60、0％（P〈0．01）。治疗前后相比，治疗组心率、血压、左室射血分数、左室舒张末期容积、左室收缩末期容积均有显著改善（P〈0．01或P〈0．05），治疗组与对照组比较差异有统计学意义（P〈0、01或P〈0．05）。结论用卡维地洛和曲美他嗪辅助治疗慢性CHF是一种安全有效的方法。

Effect of Combination of Carvedilol and Trimetazidine on Patients with Chronic Congestive Heart Failure

Objective To explore the clinical effect of combination of carvedilol and trimetazidine on chronic congestive heart failure (CHF). Methods Sixty patients with CHF were divided into two groups randomly. In control group,30 patients were treated with routine medicine, such as digitalis, diuretic agent, vasodilating agent,angiotensin converting enzyme inhibitor (ACEI),etc.Thirty patients in treatment group were added with carvedilol and trimetazidine.Results The response rate was 90.0% in treatment group, much higher than that of 60.0% in control group (P<0.01). Compared with which before treatment, there were much improvements in the heart rate, blood pressure, left ventricular ejection fraction, left ventricular end diastolic volume and left ventricular end-systolic volume in treatment group (P<0.01 or P<0.05), and the differences between the two groups were statistically significant (P<0.01 or P<0.05).Conclusions It is a safe and effective method in treating chronic CHF with combination of carvedilol and trimetazidine.