| N—酰基去氢丙氨酸衍生物对体外培养细胞的抗辐射损伤效应 |
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| 引用本文： | 李明君,Felder E.,Miehe C.,Burkat W..N—酰基去氢丙氨酸衍生物对体外培养细胞的抗辐射损伤效应[J].北京大学学报(医学版),1990(6). |
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| 作者姓名： | 李明君 Felder E. Miehe C. Burkat W. |
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| 作者单位： | 北京医科大学放射医学教研室
(李明君)，瑞士联邦原子能研究所
(Felder E.，Miehe C.)，瑞士联邦原子能研究所(Burkat W.) |
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| 摘 要： | N-酰基去氢丙氨酸衍生物,最近被推荐为新型抗辐射剂。本研究用体外培养细胞在乏氧条件下检验了其防护效应。结果表明:在低浓度下化合物无防护作用;在高浓度时则显示一定的防护效应。作者认为如果进一步改善其化学结构,使之增加水溶性而又不增加毒性,则可能有更强的抗辐射的效应。
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| 关 键 词： | N-酰基去氢丙氨酸衍生物 辐射防护剂 剂量效应 |
RADIOPROTECTIVE EFFECT OF N-ACYL DEHYDROALANINE DERIVATIVES IN VITRO CELLS CULTURES AGAINST RADIATION DAMAGE |
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| Li Mingjun,Felder E.,Michel C.,Burkat W.RADIOPROTECTIVE EFFECT OF N-ACYL DEHYDROALANINE DERIVATIVES IN VITRO CELLS CULTURES AGAINST RADIATION DAMAGE[J].Journal of Peking University:Health Sciences,1990(6). |
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| Authors: | Li Mingjun Felder E Michel C Burkat W |
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| Institution: | Li Mingjun;Felder E.;Michel C.;Burkat W.Beijing Medical University Paul Scnerre Institute Switzerland |
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| Abstract: | N-Acyl Dehydroalanine derivatives have recently been proposed as candidates for a new class ofradioprotective agent. The radioprotective effects on cell culture under hypoxic conditions were studied.The results showed: at low concentration the compounds showed no protective cffects; at high concentr-ation showed some protective effects. If the chemical structure of the compounds is modified with theaim to increase water solubility without compromising the cytotoxicity, the stronger protective effectwill be expected. |
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| Keywords: | N-Acyl Dehydroalanine derivatives Radioprotective agent Dose-effect |
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