| 反应停治疗难治性多发性骨髓瘤6例 |
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| 引用本文： | 陈文新,李新,刘雪梅,包翠华. 反应停治疗难治性多发性骨髓瘤6例[J]. 内蒙古医学杂志, 2003, 35(6): 497-499 |
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| 作者姓名： | 陈文新 李新 刘雪梅 包翠华 |
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| 作者单位： | 1. 内蒙古医学院第三附属医院血液科,内蒙古,包头,014010
2. 呼和浩特市新城区医院,内蒙古,呼和浩特,010010 |
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| 摘 要： | 目的：探讨反应停治疗难治性多发性骨髓瘤(MM)的临床疗效。方法：对6例难治疗性多发性骨髓瘤应用反应停治疗后的临床资料进行分析，并结合文献复习，为该病的治疗提供一条思路。结果：1例患者达完全缓解；1例患者达部分缓解；1例进步，血清M蛋白减少35％、骨痛明显减轻、血沉降低40％、血红蛋白上升20g／L；2例无效；1例死亡。结论：反应停对多发性骨髓瘤有较好的疗效，不良反应可以耐受且不产生骨髓抑制：抗血管新生是其主要疗效机制。
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| 关 键 词： | 难治性多发性骨髓瘤 反应停 药物治疗 抗血管新生 疗效 |
| 文章编号： | 1004-0951(2003)06-0497-03 |
| 修稿时间： | 2003-04-25 |
Thalidomide in Therapy of Refractory Multiple Myeloma: Report of 6 Cases |
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| CHEN Wen-xin,LI Xin,LIU Xue-mei,BAO Chui-hua. Thalidomide in Therapy of Refractory Multiple Myeloma: Report of 6 Cases[J]. Inner Mongolia Medical Journal, 2003, 35(6): 497-499 |
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| Authors: | CHEN Wen-xin LI Xin LIU Xue-mei BAO Chui-hua |
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| Abstract: | Objective:To inquire the treatment outcome of thalidomide for refractory multiple myiloma.Method:The clinical data of t myeloma treated with thalicomide were reviewed.Result:The were 1 case remitted,1 case remitted partly,1 case effective with decreased serum M protein(35%),relieved ostalgia,lower erythrocyte sedimentation rate (CSR)(40%) and increased hemoglobin(20g/L),2 cases ineffective and 1 case dead.Conclusion:Thalidomide is effective for multiple myeloma with tolerable side-effect and noninhibiton of bone marrow.Antivascularization is its main mechanism. |
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| Keywords: | Multiple myeloma Thalidomide Therapy |
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