| 皮脂腺肿瘤p53及bcl-2蛋白表达的研究 |
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| 引用本文： | 张士发,林俊萍,梁再赋,张欣,顾绍裘. 皮脂腺肿瘤p53及bcl-2蛋白表达的研究[J]. 中国皮肤性病学杂志, 1999, 0(1) |
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| 作者姓名： | 张士发 林俊萍 梁再赋 张欣 顾绍裘 |
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| 作者单位： | 沈阳军区总医院皮肤科，中国医科大学第一临床学院皮肤科 |
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| 摘 要： | 目的研究ｐ５３及ｂｃｌ ２基因在皮脂腺肿瘤中的作用。方法应用免疫组化方法对皮脂腺良、恶性肿瘤上述两种基因产物的表达进行了检测。结果５例皮脂腺癌、２例皮脂腺痣和２例皮脂腺增生症均不同程度表达ｂｃｌ ２蛋白，而ｐ５３蛋白仅表达于５例皮脂腺癌的癌细胞。两种蛋白表达强度无相关关系（ｒ’ｓ＝０．１０５，Ｐ＞０．０５）。结论ｐ５３基因突变在皮脂腺癌发生中起决定性作用，而ｂｃｌ ２基因则起协同促进作用。检测ｐ５３蛋白可用于鉴别皮脂腺良、恶性肿瘤。
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| 关 键 词： | 皮脂腺肿瘤 蛋白质p~(53) 蛋白质bcl |
Study of the Expression of p53 and bcl 2 Protrin in Sebaceous Tumors. |
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| Zhang Shifa,Lin Junping,Liang Zaifu,et al.. Study of the Expression of p53 and bcl 2 Protrin in Sebaceous Tumors.[J]. The Chinese Journal of Dermatovenereology, 1999, 0(1) |
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| Authors: | Zhang Shifa Lin Junping Liang Zaifu et al. |
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| Affiliation: | Zhang Shifa,Lin Junping,Liang Zaifu,et al.Department of Dermatology,General Hospital of Shenyang Military Region,Shengyang,110015 |
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| Abstract: | Objective To study the role of p53 and bcl 2 genes in the genesis of sebaceous tumors.Methods The expression of two gene's products were detected using immunohistochemical method.Results The bcl 2 protein was ununiformly expressed in 5 cases of sebaceous gland carcinoma,2 cases of sebaceous nevus and 2 cases of sebaceous hyperplasia,the expression of p53 protein was only seen in tumor cells of 5 cases of sebaceous gland carcinoma.The expressive intensity of two kinds of proteins had no correlation each other(r's=0.105,P>0.05).Conclusion Mutant p53 gene plays an key role in the genesis of sebaceous gland carcinoma,and bcl 2 gene may exert synergistic role in it.The detection of p53 protein may be useful for the differentiation between benign and malignant sebaceous tumors. |
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| Keywords: | Sebaceous gland neoplasms Protein p53 Protein bcl 2 |
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