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皮脂腺肿瘤p53及bcl-2蛋白表达的研究
引用本文:张士发,林俊萍,梁再赋,张欣,顾绍裘.皮脂腺肿瘤p53及bcl-2蛋白表达的研究[J].中国皮肤性病学杂志,1999(1).
作者姓名:张士发  林俊萍  梁再赋  张欣  顾绍裘
作者单位:沈阳军区总医院皮肤科,中国医科大学第一临床学院皮肤科
摘    要:目的研究p53及bcl 2基因在皮脂腺肿瘤中的作用。方法应用免疫组化方法对皮脂腺良、恶性肿瘤上述两种基因产物的表达进行了检测。结果5例皮脂腺癌、2例皮脂腺痣和2例皮脂腺增生症均不同程度表达bcl 2蛋白,而p53蛋白仅表达于5例皮脂腺癌的癌细胞。两种蛋白表达强度无相关关系(r’s=0.105,P>0.05)。结论p53基因突变在皮脂腺癌发生中起决定性作用,而bcl 2基因则起协同促进作用。检测p53蛋白可用于鉴别皮脂腺良、恶性肿瘤。

关 键 词:皮脂腺肿瘤  蛋白质p~(53)  蛋白质bcl

Study of the Expression of p53 and bcl 2 Protrin in Sebaceous Tumors.
Zhang Shifa,Lin Junping,Liang Zaifu,et al..Study of the Expression of p53 and bcl 2 Protrin in Sebaceous Tumors.[J].The Chinese Journal of Dermatovenereology,1999(1).
Authors:Zhang Shifa  Lin Junping  Liang Zaifu  
Affiliation:Zhang Shifa,Lin Junping,Liang Zaifu,et al.Department of Dermatology,General Hospital of Shenyang Military Region,Shengyang,110015
Abstract:Objective To study the role of p53 and bcl 2 genes in the genesis of sebaceous tumors.Methods The expression of two gene's products were detected using immunohistochemical method.Results The bcl 2 protein was ununiformly expressed in 5 cases of sebaceous gland carcinoma,2 cases of sebaceous nevus and 2 cases of sebaceous hyperplasia,the expression of p53 protein was only seen in tumor cells of 5 cases of sebaceous gland carcinoma.The expressive intensity of two kinds of proteins had no correlation each other(r's=0.105,P>0.05).Conclusion Mutant p53 gene plays an key role in the genesis of sebaceous gland carcinoma,and bcl 2 gene may exert synergistic role in it.The detection of p53 protein may be useful for the differentiation between benign and malignant sebaceous tumors.
Keywords:Sebaceous gland neoplasms  Protein p53  Protein bcl  2  
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