伤寒并发中毒性肝炎的肝功能分析

目的 :探讨伤寒杆菌对肝脏的损害和对肝功能的影响。方法 :对 35 0例伤寒患者肝功能及乙型肝炎病毒(HBV)标记物的检测结果进行分析。结果 :2 30例 (6 5 .7% )出现ALT和AST升高 ,其中 83例 (36 .1% )伴有血清总胆红素 (STB)升高 ;32 0例进行HBV标记物检测 ,发现HBV感染 4 5例 ,伤寒重叠HBV感染率为14 .1% ,重叠感染组的ALT ,AST及STB均值比单纯感染组显著升高 (P <0 .0 5 )。结论 :伤寒患者中肝损害较常见 ,其中重叠HBV感染者肝损害程度更重 ,但重叠HBV感染者中肝损害的发生率并无明显升高。

LIVER FUNCTION OF TYPHOID FEVER COMPLICATED WITH TOXIC HEPATITIS

Objective:To investigate the liver lesion and changes of liver function in Salmonella typhia. Methods:A retrospective analysis on the laboratory tests of liver function and hepatitis B virus markers in 350 cases of typhoid fever was carried out.Results:Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were observed in 230(65.7%) cases, of which 83 (36.1%) cases had elevated serum total bilirubin (STB). In cases who had HBV markers tests, the results showed that 45 out of 320 cases were infected by HBV. The rate of superinfection was 14.1%. The mean of ALT,AST and STB level were significantly higher in the superinfectious group than those in the group of cases infected by Salmonella typhia only ( P <0.05). Conclusions:The liver lesion is commonly observed in typhoid fever,and the liver lesion in HBV superinfectious group is more severe than that in typhoid fever group, but the rate of occurrence of liver lesion in the superinfectious cases seems to be not elevated significantly.