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基质金属蛋白酶-2、9及其抑制剂-1在大肠腺癌中表达的研究
引用本文:陈谦,柯娟,王纪全,邓怀慈. 基质金属蛋白酶-2、9及其抑制剂-1在大肠腺癌中表达的研究[J]. 陕西医学杂志, 2009, 38(2)
作者姓名:陈谦  柯娟  王纪全  邓怀慈
作者单位:西安交通大学医学院第一附属医院肿瘤放疗科,西安,710061
摘    要:目的:探讨人大肠腺癌组织中MMP-2、MMP-9和TIMP-1的表达及其临床意义。方法:采用免疫组织化学方法(SP)检测MMP-2、MMP-9和TIMP-1在30例大肠癌组织及相应切缘正常组织中的蛋白表达。结果:大肠癌组织中MMP-2、MMP-9及TIMP-1阳性表达明显高于正常切缘组织(P<0.05),并与肿瘤分化程度、浸润深度、Dukes分期以及有无淋巴结转移密切相关(P<0.05);MMP-9和TIMP-1表达明显相关(r=0.4924,P<0.05)。结论:MMP2、MMP9、TIMP1的过度表达与大肠腺癌的侵袭、转移有密切关系,其联合检测有助于评估大肠腺癌恶性生物学行为及预后。

关 键 词:结肠肿瘤  直肠肿瘤  免疫组织化学  基质金属蛋白酶  金属蛋白酶1组织抑制剂

Expression of MMP-2, MMP-9 and TIMP-1 in human colorectal cancer
Abstract:Objective:To study the significance of matrix metalloproteinase-2(MMP-2), matrix metalloproteinase-9 (MMP-9) and their inhibitor tissue inhibitor of metalloproteinase TIMP-1 expressions in human colorectal cancer. Methods:The expressions of MMP2,MMP9 and TIMP1 in 30 primary colorectal tumors and adjacent noncancerous tissues were detected by immunohistochemical S-P method. Results:The positive rates of MMP-2,MMP-9 and TIMP-1 in colorectal cancer were significantly higher than those in adjacent noncancerous tissues(P<0.05),and which were closely associated with tumor differentiation ,Dukes stages, progression of invasion depth and lymph node metastasis (P<0.05).A close correlation was present between MMP-9 and TIMP-1 expression(r=0.4924,P<0.05). Conclusion: Over expressions of MMP2,MMP9,TIMP-1 are obviously correlated with both invasion and metastasis in colorectal cancer , Combined detecting of which may be helpful to determining colorectal cancer biological behavior and prognosis.
Keywords:Colornic neoplasms Rectal neoplasms Immunohistochemistry Matrix metalloproteinase Tissue inhibitor-of metalloproteinase-1
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