强迫症患者前额叶、海马磁共振质子波谱成像的研究

目的探讨强迫症患者前额叶、海马的磁共振质子波谱(1H-MRS)的变化特点。方法应用1H-MRS成像技术检测10例强迫症患者(强迫症组)和10名健康对照者(对照组)的前额叶、海马N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)3种代谢物,计算NAA/Cr、Cho/Cr比值。结果强迫症组患者双侧前额叶和左侧海马的NAA/Cr均高于对照组,差异均有统计学意义(均P<0.05)。强迫症组患者右侧前额叶NAA明显高于对照组,差异有统计学意义(P<0.05)。强迫症组患者双侧海马Cho/Cr、右侧海马Cho均高于对照组,差异均有统计学意义(P<0.05)。结论强迫症患者双侧前额叶、左侧海马的神经元活力有增高迹象,同时海马的细胞膜代谢可能存在异常。

1H magnetic resonance spectroscopy imaging of prefrontal region and hippocampus in patients with obsessive-compulsive disorder

Objective To investigate potential irregularities in neurochemical compounds in obsessive-compulsive disorder(OCD) using proton magnetic resonance spectroscopy(1H-MRS) .Methods 1H-MRS was performed on prefrontal region and hippocampus in 10 patients with obsessive-compulsive disorder and 10 controls.The N-acetyl aspartic acid(NAA) ,choline(Cho) and creatine(Cr) were measured and the ratios of NAA/Cr and Cho/Cr were determined.Independent sample t-tests were used for statistical analysis.Results The NAA/Cr ratios in prefrontal region and left hippocampus in patients were higher than that in normal controls(P<0.05) .The NAA in right prefrontal region in patients were higher than that in normal controls(P<0.05) .The Cho/Cr ratios in hippocampus and the Cho in right hippocampus in patients were higher than that in normal controls(P<0.05) .Conclusion There might be both abnormal metabolism of membrane in hippocampus and increased neuronal vitality in prefrontal region and left hippocampus in patients with obsessive-compulsive disorder.