Transplantation of fetal and xenogeneic nervous tissue in Parkinson's disease |
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| Authors: | S V Savel'ev V V Lebedev S V Voityna L I Korochkin E M Molnar G T Sukhikh |
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| Institution: | (1) Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow;(2) N. V. Sklifosovskii Research Institute of Emergency Medicine, Russian Academy of Medical Sciences, Moscow;(3) Institute of Gene Biology, Russian Academy of Sciences, Moscow;(4) International Institute of Biological Medicine, Moscow |
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| Abstract: | A mixture of fetal human brain tissue and of neural primordia of NotchDrosophila melanogaster is transplanted to the ventrolateral thalamic nucleus of patients with Parkinson's disease in stage 3–4. Two kinds of operation
are performed. In the first case cryodestruction of the zone of tissue implantation is performed before transplant, and in
the second case this procedure is not performed. A stable effect manifested in the disappearance of tremor and rigidity is
achieved for both kinds of operation. When a transplant is performed without cryodestruction, the effect does not manifest
itself until 2 months postoperation. The patients are followed up for 7–12 months postoperation. No side effects or relapses
of Parkinson's disease are observed in this period.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
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4, pp. 369–372, April, 1994
Presented by N. K. Permyakov, Member of the Russian Academy of Medical Sciences |
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| Keywords: | transplantation nervous system fetal tissue xenografts |
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