| 食管癌APC／MCC,DCC的基因杂合丢失的研究 |
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| 引用本文： | 王明荣,鲁荣.食管癌APC／MCC,DCC的基因杂合丢失的研究[J].中华肿瘤杂志,1999,21(1):16-18. |
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| 作者姓名： | 王明荣 鲁荣 |
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| 作者单位： | 重庆第三军医大学西南医院心胸外科 |
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| 摘 要： | 目的 研究ＡＰＣａｄｅｎｏｍａｔｏｕｓ ｐｏｌｙｐｏｓｉｓ ｃｏｌｉ），ＭＣＣ（ｍｕｔａｔｉｏｎ ｉｎ ｃｏｌｏｒｅｃｔａｌ ｃａｎｃｅｒ和ＤＣＣ（ｄｅｌｅｔｅｄ ｉｎ ｃｏｌｏｒｅｃｔａｌ ｃａｎｃｒ）基因在人食管癌组织中的变化。方法 采用聚合酶链反应（ＰＣＲ）及限制性片段长度多态现象（ＲＦＬＰ）法检测了４６例食管癌组织中ＡＰＣ、ＭＣＣ和ＤＣＣ基因的杂合缺失。结果 ＡＰＣ、ＭＣＣ和ＤＣＣ位点的杂
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| 关 键 词： | 食管肿瘤 基因缺失 杂合丢失 APC MCC DCC |
The possible role of loss of heterozygosity at APC, MCC and DCC genetic loci in esophageal carcinoma] |
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| M Wang,R Lu,D Fang.The possible role of loss of heterozygosity at APC, MCC and DCC genetic loci in esophageal carcinoma][J].Chinese Journal of Oncology,1999,21(1):16-18. |
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| Authors: | M Wang R Lu D Fang |
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| Institution: | Southwest Hospital, Third Military Medical University, Chongqing 400038. |
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| Abstract: | OBJECTIVE: To investigate the alterations of APC, MCC and DCC genes in human esophageal carcinoma. METHODS: A total of 46 human esophageal cancer specimens were analyzed for the loss of heterozygosity (LOH) at APC, MCC and DCC genetic loci by means of polymerase chain reaction and restriction fragment length polymorphism. RESULTS: The incidence of LOH was 29.0%(9/31) at APC locus, 33.3%(8/24) at MCC locus, and 32.4%(12/37) at DCC locus, respectively. However, there was no statistically significant correlation between LOH at these three loci with such clinical parameters as pathological types, tumor size, invasiveness, and lymph-node metastasis. CONCLUSION: These data suggest that LOH at APC, MCC and DCC loci in esophageal carcinoma is, to certain extent, a common genetic alteration which might play a role in esophageal carcinogenesis. |
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