首页 | 本学科首页   官方微博 | 高级检索  
检索        

用于肾移植的几种免疫抑制方案的对比研究
引用本文:徐达,刘永,王祥慧,唐孝达.用于肾移植的几种免疫抑制方案的对比研究[J].中华器官移植杂志,2000,21(5):285-287.
作者姓名:徐达  刘永  王祥慧  唐孝达
作者单位:上海市第一人民医院肾脏移植中心,200080
摘    要:目的 比较肾移植后几种常用免疫抑制治疗方案的疗效与副作用。方法 根据所使用的免疫抑制治疗方案将87例肾移植患者分为4组,A组的免疫抑制治疗方案为他克莫司(FK506)、霉酚酸酯(MMF)和泼尼松(Pred);B线为环孢素A(CsA)、MMF和Pred;C组为CsA、硫唑嘌呤(Aza)和Pred;D组为CsA和Pred。观察术后移植肾功能的恢复情况、排斥反应发生率、并发症及免疫抑制剂用量的变化。结果

关 键 词:肾移植  免疫抑制剂  对比研究  他克莫司  霉酚酸酯

Comparative study of current immunosuppression regimens for renal transplantation
XU Da,LIU Yong,WANG Xianghui,et al..Comparative study of current immunosuppression regimens for renal transplantation[J].Chinese Journal of Organ Transplantation,2000,21(5):285-287.
Authors:XU Da  LIU Yong  WANG Xianghui  
Institution:XU Da,LIU Yong,WANG Xianghui,et al. Department of Renal Transplantation,Shanghai First People's Hospital,Shanghai 200080,China
Abstract:Objectives To compare the therapeutic effects and side effects of four immunosuppression regimens for renal transplantation. Methods According to different drug combinations, 87 allograft recipients were divided into four groups: group A receiving FK506, MMF and Pred; group B receiving CsA, MMF and Pred; group C receiving CsA, Aza and Pred; group D receiving CsA and Pred. The recovery of renal function, survival rate, rejection episodes, complications and the changes in doses of immunosuppressive agents were observed. Results One-year survival rate in the groups A, B, C and D was 100*!%, 96.9 *!%, 85.7 *!% and 100*!% respectively. Rejection episodes in each group were 0 (group A), 5 (group B), 11 (group C) and 10 (group D). The infection rate in groups A and B was higher than in the groups C and D ( P < 0.05 ). The rate of transient liver function abnormality in groups C and D was higher than in groups A and B at the early stage after operation. CsA dosage in each group was gradually decreased and so did the dosage of hormone after operation. Conclusions Varied immunosuppression regimens should be selected due to differences in individuals and complexity of immune system.
Keywords:Kidney transplantation  Immunosuppressive agents  Comparative study
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号