用于肾移植的几种免疫抑制方案的对比研究

目的 比较肾移植后几种常用免疫抑制治疗方案的疗效与副作用。方法 根据所使用的免疫抑制治疗方案将８７例肾移植患者分为４组，Ａ组的免疫抑制治疗方案为他克莫司（ＦＫ５０６）、霉酚酸酯（ＭＭＦ）和泼尼松（Ｐｒｅｄ）；Ｂ线为环孢素Ａ（ＣｓＡ）、ＭＭＦ和Ｐｒｅｄ；Ｃ组为ＣｓＡ、硫唑嘌呤（Ａｚａ）和Ｐｒｅｄ；Ｄ组为ＣｓＡ和Ｐｒｅｄ。观察术后移植肾功能的恢复情况、排斥反应发生率、并发症及免疫抑制剂用量的变化。结果

Comparative study of current immunosuppression regimens for renal transplantation

Objectives To compare the therapeutic effects and side effects of four immunosuppression regimens for renal transplantation. Methods According to different drug combinations, 87 allograft recipients were divided into four groups: group A receiving FK506, MMF and Pred; group B receiving CsA, MMF and Pred; group C receiving CsA, Aza and Pred; group D receiving CsA and Pred. The recovery of renal function, survival rate, rejection episodes, complications and the changes in doses of immunosuppressive agents were observed. Results One-year survival rate in the groups A, B, C and D was 100*!%, 96.9 *!%, 85.7 *!% and 100*!% respectively. Rejection episodes in each group were 0 (group A), 5 (group B), 11 (group C) and 10 (group D). The infection rate in groups A and B was higher than in the groups C and D ( P < 0.05 ). The rate of transient liver function abnormality in groups C and D was higher than in groups A and B at the early stage after operation. CsA dosage in each group was gradually decreased and so did the dosage of hormone after operation. Conclusions Varied immunosuppression regimens should be selected due to differences in individuals and complexity of immune system.