盐酸米诺环素软膏与丁硼乳膏治疗急性局限型智齿冠周炎的临床观察

目的：比较盐酸米诺环素软膏（minocycline hydrochloride ointment，商品名为派丽奥）与丁硼乳膏（商品名雅皓乳膏）治疗急性局限型智齿冠周炎的疗效，并以碘甘油治疗作对照。方法：选取急性局限型智齿冠周炎276例．分为3组，局部用3％过氧化氢和生理盐水交替冲洗后擦干，采用以下方式局部给药：A组注入适量盐酸米诺环素仅1次：B组将少量丁硼乳膏停留患区5min后漱13，3次／d，共3d；C组局部置入2％碘甘油，1次／d，共3d。所有治疗组均未全身用药，第4天观察疗效。结果：A、B组症状均有明显改善，总有效率分别为94．68％和87．78％．两组间疗效无显著性差异（P〉0．05）。但A、B组的疗效均好于C组（63．04％），P〈0．01。结论：盐酸米诺环素与丁硼乳膏治疗急性局限型智齿冠周炎均有较好疗效，其效果明显优于对照组。

Clinical Observation on Treatment of Acute Wisdom Tooth Pericoronitis with Minocycline Hydrochioride Ointment or Dingpeng Cream

Objective:To study the efficacy of minocycline hydrochloride ointment and Dingpeng cream of curing acute wisdom tooth pericoronitis,comparing with iodine glycerine.Methods:276 cases of acute wisdom tooth pericoronitis were selected and randomly separated into 3 groups,whose local parts were washed with 3% hydrogen peroxide,and physiological saline consecutively,and dried clearly.For patients in group A,minocycline hydrochloride ointment was injected on their infected areas once.For patients in group B,Dingpeng cream was left in infected areas for 5 minutes then removed(repeated 3 times everyday in 3 days).Patients in Group C were treated with 2% iodine glycerine once everyday in 3 days.Efficacy of all experimental treatments were observed at the 4th day.Result:The symptoms of group A and B were mitigated obviously,whose ratio of effectiveness was 94.68% and 87.78% respectively,without significant difference(P>0.05),and were all better than that of group C(63.04%),P<0.01.Conclusion:Both mincycline hydrochloride ointment and Dingpeng cream are good in curing acute wisdom tooth pericoronitis.