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Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis |
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| Authors: | Julià Eva Montalban Xavier Al-Zayat Hammad Issazadeh-Navikas Shohreh Goertsches Robert Martin Roland Comabella Manuel |
| Affiliation: | aUnitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain bDepartment of Experimental Medical Science, Section for Medical Inflammation Research, University of Lund, Lund, Sweden |
| Abstract: | OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS. |
| Keywords: | T cells Apoptosis Multiple sclerosis |
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