Evaluation of persistent antimicrobial effects of an antimicrobial formulation |
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Authors: | Ferrara Michael S Courson Ron Paulson Daryl S |
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Institution: | Department of Kinesiology, University of Georgia, Athens, GA 30602, USA. mferrara@uga.edu |
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Abstract: | Context:Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is becoming more prevalent in healthy athletic populations. Various preventive measures have been proposed, but few researchers have evaluated the protective effects of a prophylactic application of a commercially available product.Objective:To compare the persistent antimicrobial properties of a commercially available antimicrobial product containing 4% chlorhexidine gluconate (Hibiclens) with those of a mild, nonmedicated soap (Dr. Bronner''s Magic Soap).Design:Cross-sectional study.Setting:Microbiology laboratory, contract research organization.Patients or Other Participants:Twenty healthy human volunteers.Intervention(s):The test and control products were randomly assigned and applied to both forearms of each participant. Each forearm was washed for 2 minutes with the test or control product, rinsed, and dried. At, 1, 2, and 4 hours after application, each forearm was exposed to MRSA for approximately 30 minutes.Main Outcome Measure(s):Differences in numbers of MRSA recovered from each forearm, test and control, at each postapplication time point were compared.Results:Fewer MRSA (P < .0001) were recovered from the forearms treated with the test product (4% chlorhexidine gluconate) than from the forearms treated with the control product (nonmedicated soap).Conclusions:The 4% chlorhexidine gluconate product demonstrated persistent bactericidal activity versus MRSA for up to 4 hours after application. |
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Keywords: | methicillin-resistant Staphylococcus aureus chlorhexidine gluconate skin infections |
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