| Regulation of ApoE Gene Expression in Mouse Peritoneal Macrophages by VLDL |
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| 引用本文： | 冯友梅,从容,宗义强,张建民,屈伸,邓耀祖. Regulation of ApoE Gene Expression in Mouse Peritoneal Macrophages by VLDL[J]. 华中科技大学学报(医学英德文版), 1997, 17(2): 65-67. DOI: 10.1007/BF02888235 |
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| 作者姓名： | 冯友梅 从容 宗义强 张建民 屈伸 邓耀祖 |
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| 作者单位： | Department of Biochemistry，Tongji Medical University，Wuhan 430030 |
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| 摘 要： | Macrophageisoneofprecursors0far-terialwallfoamcellsandhasbeensuggest-edtoplayanimportantroleinthedevel0p-mentofather0sclerosis.Macr0phagescantakeupApoB-0rApoE-containinglip0pro-teinsviavariouslipoproteinreceptors,whichcauseslipidaccumulationinthecells.Inaddition,macr0phagescansecreteApoE['].Thoughthisphenomenonhasbeendiscoveredf6rmanyyears,itsimplicationremainsunclear.VLDLisoneof1ip0pr0teinscontainingApoE.ItcanbetakenupbymacrophagesviaApoEmediatedreceptors.SoVLDLcanstimulatelipidaccumu…
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| 收稿时间： | 1996-07-09 |
Regulation of ApoE gene expression in mouse peritoneal macrophages by VLDL |
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| Feng Youmei,Cong Rong,Zong Yiqiang,Zhang Jianmin,Qu Shen,Deng Yaozu. Regulation of ApoE gene expression in mouse peritoneal macrophages by VLDL[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1997, 17(2): 65-67. DOI: 10.1007/BF02888235 |
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| Authors: | Feng Youmei Cong Rong Zong Yiqiang Zhang Jianmin Qu Shen Deng Yaozu |
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| Affiliation: | (1) Department of Biochemistry, Tongji Medical University, 430030 Wuhan |
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| Abstract: | Mouse peritoneal macrophages (MPM) were incubated with ApoEpoor VLDL or ApoE-rich VLDL at same concentrations for 24 h. The ApoE mR NA content increased in both groups than that in control and the highest ApoEmRNA content was seen in MPM incubated with ApoE-poor VLDL. The results suggest that VLDL could stimuIate ApoE gene expression in MPM and the ApoE poor VLDL has more pronounced effect. We think that the ApoE secreted byMPM may be incorporated into VLDL, especially the ApoE-poor VLDL, and thereby enhance the uptake of those lipoproteins by MPM or other local cells via ApoE-mediated receptor pathways. |
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| Keywords: | ApoE-poor VLDL ApoE-rich VLDL macrophages ApoE gene expression |
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