Mammographic density and its interaction with other breast cancer risk factors in an Asian population |
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Authors: | Wong C S Lim G H Gao F Jakes R W Offman J Chia K S Duffy S W |
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Affiliation: | Centre For Molecular Epidemiology, National University of Singapore, Blk MD3, 16 Medical Drive, Singapore 117597, Singapore. |
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Abstract: | Background: Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear.Methods: From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression.Results: Density was a significant risk factor, adjusting for other factors. Density of 76–100% had an odds ratio of 5.54 (95% CI 2.38–12.90) compared with 0–10%. Density had significant interactions with body mass index and oral contraceptive use (P=0.02).Conclusions: Percent density increases breast cancer risk in addition to effects of other risk factors, and modifies the effects of BMI and OCs. |
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Keywords: | Asian population body mass index breast cancer breast density mammography |
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