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| 宫颈鳞癌及癌前病变组织中ILK、PTEN的表达情况 | |
| 引用本文： | 刘春在,李春玲,李胜水,江泽,李双标,许华,张凤梅,刘岩. 宫颈鳞癌及癌前病变组织中ILK、PTEN的表达情况[J]. 中国当代医药, 2010, 17(10): 5-7 |
| 作者姓名： | 刘春在 李春玲 李胜水 江泽 李双标 许华 张凤梅 刘岩 |
| 作者单位： | 1. 河北省沧州南大港医院,河北沧州,061103 2. 河北省沧州市妇幼保健院,河北沧州,061001 3. 河北省沧州中西医结合医院,河北沧州,061001 4. 河北省沧州市中心医院,河北沧州,061001 |
| 摘 要： | 目的：探讨宫颈鳞癌及癌前病变组织中整合素连接激酶（ILK）、PTEN的表达情况。方法：采用免疫组化方法对50例宫颈鳞癌,28例CIN和12例正常宫颈组织进行ILK、PTEN检测,并结合临床资料进行统计分析。结果：宫颈鳞癌ILK阳性表达率明显高于正常组织和CIN1、2级组织,ILK表达与肿瘤浸润、转移和临床分期密切相关;正常宫颈组织PTEN均呈阳性表达,而宫颈浸润癌组织PTEN表达率明显降低,但PTEN表达与肿瘤浸润、转移和临床分期无明显相关性。结论：宫颈鳞癌组织ILK呈高表达、PTEN呈低表达,可能在宫颈肿瘤浸润转移过程中起重要作用。 |
| 关 键 词： | 宫颈鳞癌 整合素连接激酶 免疫组织化学 |
The expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions |
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| LIU Chunzai,LI Chunling,LI Shengshui,JIANG Ze,LI Shuangbiao,XU Hua,ZHANG Fengmei,LIU Yan. The expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions[J]. http://www.botanicus.org/, 2010, 17(10): 5-7 | |
| Authors: | LIU Chunzai LI Chunling LI Shengshui JIANG Ze LI Shuangbiao XU Hua ZHANG Fengmei LIU Yan |
| Affiliation: | 1.Nan Da Gang Hospital,Cangzhou 061103,China;2.Cangzhou Women ＆ Children＇s healthcare Hospital,Cangzhou 061001,China;3.Cangzhou Hospital for Integrated Chinese and Western Medicine,Cangzhou 061001,China;4.Cangzhou Central Hospital,Cangzhou 061001,China) |
| Abstract: | Objective：To study the expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions.Methods：50 cases of cervical squamous carcinoma,28 cases of cervical intraepithelial neoplasia（CIN） and 12 cases of normal cervical tissues ample were stained for ILK,PTEN by immunohistochemistry method.Results：ILK positive expression rate in cervical squamous carcinoma was significantly higher than that in normal cervical tissue and CIN I.The positive expression rate of PTEN in normal cervical tissue was 100.0%,but it was remarkably decreased in cervical squa mous carcinoma.Our analysis indicated that no significant relationship was found between the state of PTEN expression and invasion,metastasis and the clinical stage of the tumor.Conclusion：The higher expression of ILK and the lower expression of PTEN in cervical squamous carcinoma may play an important role in angiogenesis of cervical squamous carcinoma. |
| Keywords: | Cervical squamous carcinoma ILK Immunohistochemistry |
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