辛伐他汀治疗混合性高脂血症患者的疗效和耐受性

目的：观察辛伐他汀治疗混合性高脂血症患者的疗效和耐受性。方法；采用开放性、自身对比研究，对１２３例混合性高脂血症患者给予辛伐他汀１０ｍｇ，每晚一次口服，共治疗６周。结果：６周后，血清总胆固醇、低密度脂蛋白胆固醇均较治疗前明显下降（分别降低２３．８％、２９．５％，Ｐ〈０．０５），血甘油三酯也显著降低（平均降低２７．１％，Ｐ〈０．０５），高密度脂蛋白胆固醇明显上升（平均升高２３．６％，Ｐ〈０．０５）。未出现严重不良反应。结论：辛伐他汀对混合性高脂血症患者疗效明显，耐受性好。

Efficacy and Tolerance of Simvastatin in Mixed Hyperlipidemic Patients

Objective:To evaluate the efficacy and tolerance of simvastatin in treatment of mixed hyperlipidemic patients.Methods:One hundred and twenty three patients with mixed hyperlipidemia were enrolled in this study.These patients received simvastatin 10 mg,qd for 6 weeks. Results :After 6 week treatment,the serum concentrations of total cholesterol and LDL cholesterol were decreased remarkably (the average decrease being 23.8% and 29.5% respectively, P < 0.05 ),and the serum total triglyceride concentration was decreased significantly (the average decrease being 27.1%, P < 0.05 ).Meanwhile,the serum HDL cholesterol concentration was increased (the average increase being 23.6%, P <0.05).No serious side effect was observed. Conclusion :Simvastatin has a good effect and tolerance for mixed hyperlipidemic patients.